Lack of Plasma Kallikrein-Kinin System Cascade in Teleosts
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Lack of Plasma Kallikrein-Kinin System Cascade in Teleosts
The kallikrein-kinin system (KKS) consists of two major cascades in mammals: "plasma KKS" consisting of high molecular-weight (HMW) kininogen (KNG), plasma kallikrein (KLKB1), and bradykinin (BK); and "tissue KKS" consisting of low molecular-weight (LMW) KNG, tissue kallikreins (KLKs), and [Lys(0)]-BK. Some components of the KKS have been identified in the fishes, but systematic analyses have n...
متن کاملThe plasma kallikrein-kinin system counterbalances the renin-angiotensin system.
(KKS), first recognized over 40 years ago, was originally believed to contribute to physiologic hemostasis. At the time, factor XII (Hageman factor, FXII) and the related proteins prekallikrein (PK) and high molecular–weight kininogen (HK) were known to be essential for efficient surface-activated blood coagulation, as measured in the activated partial thromboplastin time (APTT) test. Indeed, i...
متن کاملKallikrein-kinin system in neovascularization.
Kinin System in Neovascularization − Kallikrein Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2009 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/ATVBAHA.109.184549 2009;29:617-619 Arterioscler Thromb Vasc Biol. http://atvb.a...
متن کاملThe renal kallikrein-kinin system.
THE KIDNEY contains several hormonal systems—kallikrein-kinin, renin-angiotensin, prostaglandin—which serve as renal self-regulatory mechanisms and may have extrarenal effects as well. Although the functions of the kallikrein-kinin system are incompletely defined, there is evidence that it may regulate renal blood flow, modulate tubular salt and water transport, and participate in the pathogene...
متن کاملThe kallikrein-kinin system in diabetic nephropathy
Diabetic nephropathy is the major cause of end-stage renal disease worldwide. Although the renin-angiotensin system has been implicated in the pathogenesis of diabetic nephropathy, angiotensin I-converting enzyme inhibitors have a beneficial effect on diabetic nephropathy independently of their effects on blood pressure and plasma angiotensin II levels. This suggests that the kallikrein-kinin s...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0081057